ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig gamma-2A chain C region, membrane-bound form

Intermolecular
Cysteine 107 of Immunoglobulin kappa constant and cysteine 14
Intramolecular
Cysteine 249 and cysteine 307
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 14 of Ig gamma-2A chain C region, membrane-bound form (214 and 428 respectively in this structure).

Details

Redox score ?
89
PDB code
1nby
Structure name
crystal structure of hyhel-63 complexed with hel mutant k96a
Structure deposition date
2002-12-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig gamma-2A chain C region, membrane-bound form
Peptide A accession
P01837
Peptide B accession
P01865
Peptide A residue number
107
Peptide B residue number
14

Ligandability

Cysteine 107 of Immunoglobulin kappa constant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of Ig gamma-2A chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig gamma-2A chain C region, membrane-bound form between cysteines 249 and 307 (367 and 425 respectively in this structure).

Details

Redox score ?
81
PDB code
6uqc
Structure name
mouse igg2a bispecific fc
Structure deposition date
2019-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01865
Residue number A
249
Residue number B
307
Peptide name
Ig gamma-2A chain C region, membrane-bound form

Ligandability

Cysteine 249 of Ig gamma-2A chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Ig gamma-2A chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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